Kidney stones | Top 21 novel treatment findings

Ultrasound-guided PCNL reduces radiation exposure

The meta-analysis found no statistically significant differences in stone-free rates, overall complications, duration of surgery, hospitalization, and hemoglobin drop between UG-PCNL and FG-PCNL. However, UG-PCNL significantly reduced radiation exposure and was associated with a lower total cost.

Study published: 2022-10-13

AI-guided percutaneous nephrostomy improves outcomes for patients with urolithiasis.

The integration of the OCT system with CNNs resulted in a high recognition accuracy of renal tissues (99.6% with InceptionV3) and effective blood vessel detection, significantly enhancing the precision of needle guidance during PCN procedures and potentially reducing complication rates.

Study published: 2024-03-21

Hypothermic Machine Perfusion reduces Delayed Graft Function in kidney transplant patients.

The study identified 72 metabolites in preservation fluids, with variations in metabolomic content based on perfusion time, although neither the metabolomic profile nor transporter expression was predictive of graft outcome.

Study published: 2021-10-01

AI system improves urinary stone treatment

The intelligent system demonstrated improved accuracy in predicting the appropriate treatment method for urinary stone disease, assisting urologists in clinical decision-making and potentially improving patient outcomes by reducing unnecessary interventions.

Study published: 2023-06-29

Third vaccine dose boosts response in KTRs

The administration of a third dose of the mRNA vaccine significantly increases anti-RBD IgG titers in kidney transplant recipients, particularly in those with low titers and the presence of spike-specific CD4+ T cells after the second dose.

Study published: 2021-08-30

Intra-operative perfusion strategies protect kidneys during surgery for acute kidney injury.

Intra-operative perfusion strategies, especially distal aortic perfusion (DAP) with LHB or pCPB, are associated with lower rates of dialysis and operative mortality compared to simple aortic cross clamping. Adjunctive SRP with cold blood or crystalloid fluids enhances kidney protection during DAP.

Study published: 2024-06-25

Hypothermic machine perfusion measures soluble DNA to predict kidney transplant function.

Higher concentrations of sDNA in the perfusate were associated with reduced graft function in the early post-transplant period, indicating its potential as a predictive biomarker for kidney transplant outcomes.

Study published: 2023-05-21

Inhibiting SLC13A5 improves kidney function in chronic kidney disease patients.

Genetically proxied SLC13A5 inhibition was associated with higher estimated glomerular filtration rates (eGFR) and lower blood urea nitrogen (BUN) levels, indicating improved kidney function.

Study published: 2023-08-29

Personalized renal replacement therapy initiation improves hospital-free days for critically ill patients with acute kidney injury.

The implementation of the personalized RRT initiation strategies resulted in an increase in average hospital-free days (HFD60) by 13.7 days for the crude strategy and 14.9 days for the stringent strategy compared to current best practices.

Study published: 2023-06-20

High calcium diet reduces kidney stones

The study found that a high calcium diet significantly decreased the occurrence of calcium stones compared to normal and low calcium diets. It also led to increased urinary volume and decreased urinary urate levels.

Study published: 2023-06-18

Intermittent exercise improves kidney function like continuous exercise in men with chronic kidney disease.

Both IE and CE significantly increased noradrenaline concentrations post-exercise, indicating a similar impact on renal function and haemodynamics without increasing acute kidney injury biomarkers.

Study published: 2024-01-26

Polymyxin B dose adjustment ineffective

No significant difference in the incidence of acute kidney injury was observed between the adjusted dosage group (37.14%) and the non-adjusted dosage group (47.5%). Secondary outcomes, including hospital length of stay, microbiological cure, clinical cure, and 30-day mortality, showed no significant differences between the two groups.

Study published: 2020-11-24

Arteriovenous fistula placement reduces hemodialysis costs for patients with chronic end-stage renal disease.

AVF placement is associated with cost savings for patients compared to other access methods. It is the preferred method for hemodialysis, leading to better quality of care and improved survival rates.

Study published: 2024-02-08

Booster enhances antibody response in patients

Post-booster, 93% of dialysis patients and 58% of transplant patients achieved protective antibody levels (≥59 AU/ml), compared to only 35% and 11% respectively before the booster. The study indicates that the third dose resulted in a significant increase in antibody levels, particularly in kidney transplant recipients, suggesting a more robust and sustainable immune response.

Study published: 2021-10-20

Dialysis modality impacts mortality rates

The study found no statistically significant differences in mortality rates among patients undergoing different dialysis modalities, suggesting that mortality is a common complication across all types of dialysis.

Study published: 2023-02-15

COVID-19 altered ureteric stone management

Despite lower admission rates and fewer invasive procedures during the pandemic, the success rate of primary treatment modalities remained similar between the two cohorts, suggesting that conservative management strategies were effective.

Study published: 2022-06-28

Stem cell therapy improves COVID-19 outcomes in patients with acute renal injury.

Patients receiving stem cell treatment showed improved renal function, reduced incidence of sepsis (25% vs 65%), improved lymphocyte counts, lower CRP levels, and shorter hospital stays compared to the control group.

Study published: 2020-12-18

Low dihydrolipoamide S-succinyltransferase levels worsen prognosis in clear cell renal cell carcinoma.

The study indicates that low expression of DLST is associated with poor prognosis in ccRCC patients, suggesting that it could serve as an independent prognostic factor. The findings support the potential of DLST as a diagnostic and prognostic biomarker, which may lead to improved patient outcomes through targeted therapies.

Study published: 2023-04-28

HAART treatment declines kidney function in HIV patients with renal dysfunction.

Despite the decline in renal function, HAART is still considered essential for managing HIV, as it helps in controlling the viral load and improving overall health outcomes in patients.

Study published: 2022-10-01

Inactivated SARS-CoV-2 vaccine boosts immune response in kidney transplant recipients

The study found that while humoral immune responses (anti-RBD IgG titers) were significantly lower in kidney transplant recipients compared to controls, cell-mediated immune responses (T-cell responses) were significantly increased post-vaccination and comparable to those in controls.

Study published: 2021-08-04

Monitoring renal venous oxygen pressure improves kidney function in end-stage renal disease patients.

A higher renal venous oxygen pressure (PO) was associated with lower serum creatinine (SCr) levels and higher glomerular filtration rate (GFR) five days after kidney transplantation, indicating better renal function.

Study published: 2023-06-16